Ziconotide acetate(CAS#107452-89-1)
| UN IDs | 3172 |
| WGK Germany | 3 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
Ziconotide acetate(CAS#107452-89-1)
Physicochemical properties
Appearance: Usually white to off-white powder.
Solubility: It has a certain solubility in water and can be dissolved in some polar organic solvents.
pharmachologic effect
Mechanism of action: It is an omega-conotoxin that specifically acts on an N-type voltage-gated calcium channel, and by binding to a specific part of the channel, it prevents the influx of calcium ions, thereby inhibiting the release of neurotransmitters, especially blocking the transmission of pain signals, thereby exerting a powerful analgesic effect.
Clinical application: It is mainly used for the treatment of severe chronic pain, especially for those patients who do not respond well to conventional analgesics, such as cancer pain, neuropathic pain, etc. It can be administered by intrathecal injection and directly acts on the spinal cord level, which can produce significant analgesic effects without affecting other sensory and motor functions, providing a new and effective treatment option for patients with chronic pain.
Synthesis method
Solid-phase synthesis is usually used, amino acids are used as raw materials, and polypeptide chains with specific sequences are constructed by gradually connecting amino acid fragments, and then after a series of reaction and modification steps, ciconotide is finally obtained, and then salted with acetic acid to obtain ziconottide acetate. This process requires strict control of reaction conditions and steps to ensure the purity and activity of the product.
Safety Information
Adverse reactions: It may cause adverse reactions such as dizziness, nausea, vomiting, nystagmus, and unsteady gait, and some patients may also have psychiatric symptoms, such as hallucinations, anxiety, etc. The occurrence of these adverse reactions may be related to the effect of the drug on the nervous system.
Precautions: When using, you must strictly follow the doctor’s instructions, and the intrathecal injection operation must be carried out by professional medical personnel to ensure the accurate administration of the drug. At the same time, it is necessary to closely monitor the vital signs and nervous system function of patients, and should be used with caution or contraindicated for patients with severe cardiovascular disease, liver and kidney insufficiency, psychiatric diseases, etc.
