Z-PYR-OH（CAS# 32159-21-0)
| Risk Codes | R22/22 - R36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. S44 - S35 – This material and its container must be disposed of in a safe way. S28 – After contact with skin, wash immediately with plenty of soap-suds. S7 – Keep container tightly closed. S4 – Keep away from living quarters. |
| WGK Germany | 3 |
| HS Code | 29337900 |
Introduction
Cbz-pyroglutamic acid (carbobenzoxy-L-phenylalanine) is an organic compound that is commonly used as an amino acid protecting group in chemistry. Its chemical properties are white crystalline solid, soluble in organic solvents such as ethanol and chloroform, insoluble in water.
One of the main uses of CBZ-pyroglutamic acid is to act as a protecting group of amino acids in solid-phase synthesis. It can form a stable amide structure by reacting with the α-amino group of amino acids to prevent other reactions from occurring. When synthesizing peptides or proteins, Cbz-pyroglutamic acid can be used to selectively protect specific amino acid residues.
The method of preparing Cbz-pyroglutamic acid is generally to react pyroglutamic acid with dibenzoyl carbonate (prepared by the reaction of dibenzoyl chloride and sodium carbonate) under alkaline conditions. The preparation process needs to be handled carefully to avoid side reactions or harmful substances.
Safety information: Cbz-pyroglutamic acid is a combustible substance, avoid direct contact with ignition sources. Appropriate protective equipment, such as laboratory gloves and glasses, should be worn during handling. Avoid inhaling its dust or solution as it may cause irritation to the respiratory system. During storage and handling, care should be taken to seal the container and keep it away from fire sources and flammable materials.
