tert-butyl 5-oxo-L-prolinate（CAS# 35418-16-7)
| Hazard Symbols | Xi – Irritant |
| Risk Codes | 36/38 – Irritating to eyes and skin. |
| Safety Description | 26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29339900 |
Introduction
tert-butyl 5-oxo-L-prolinate(tert-butyl 5-oxo-L-prolinate) is an organic compound whose chemical formula is C9H15NO3.
Nature:
tert-butyl 5-oxo-L-prolinate is a white crystalline solid that is stable at ambient temperatures. Its solubility is relatively low, soluble in some organic solvents such as ethanol and dimethylformamide.
Use:
tert-butyl 5-oxo-L-prolinate is commonly used as an optically active substance, and is often used as a substrate or ligand for chiral catalytic reactions in organic synthesis. It has good chemical stability and excellent stereoselectivity, and is widely used in pharmaceutical, material science and pesticide fields.
Preparation Method:
tert-butyl 5-oxo-L-prolinate has a variety of preparation methods, and the common method is to synthesize by job isotope exchange or acetic anhydride method. First, the intermediate of tert-butyl pyroglutamate is obtained by reacting pyroglutamic acid with tert-butoxyl chloride, which is converted to the tert-butyl 5-oxo-L-prolinate by an appropriate method.
Safety Information:
tert-butyl 5-oxo-L-prolinate has low toxicity, laboratory safety procedures still need to be followed. Avoid contact with skin and eyes. Wear protective gloves and safety glasses if necessary. Avoid producing dust or gas during operation or storage. Seek immediate medical assistance if exposed or inhaled.
