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Sinapinic Acid(CAS#530-59-6)

Chemical Property:

Molecular Formula C11H12O5
Molar Mass 224.21
Density 1.1478 (rough estimate)
Melting Point ~202 °C
Boling Point 285.61°C (rough estimate)
Flash Point 158.6°C
Water Solubility insoluble
Solubility Soluble in hot ethanol, slightly soluble in water and ether.
Vapor Presure 3.12E-07mmHg at 25°C
Appearance Crystallization
Color white
BRN 2130006
pKa 4.53±0.10(Predicted)
Storage Condition Keep in dark place,Sealed in dry,Room Temperature
Stability Stable. Incompatible with strong oxidizing agents, strong bases. Combustible.
Refractive Index 1.4720 (estimate)
MDL MFCD00004401
Physical and Chemical Properties White powder, soluble in chloroform, ether, methanol, derived from rapeseed meal.
In vitro study Sinapinic acid acts as an inhibitor of HDAC, with an IC 50 of 2.27 mM. Sinapinic acid also inhibits ACE-I activity. Sinapinic acid inhibits HDAC activity in HeLa cells, suppresses the growth of HeLa and HT29 cells with IC 50 s of 0.91 ± 0.02 mM and 1.6 ± 0.02 mM at 72 h, respectively, induces apoptosis of these cancer cells.
In vivo study Sinapinic acid (5 or 25 mg/kg, p.o. daily for 4 weeks) increases the serum estradiol concentration; decreases insulin resistance and the triglyceride and total cholesterol concentrations; and favorably affects the parameters of antioxidant abilities (reduces glutathione, superoxide dismutase) and oxidative damage in rats.

Product Detail

Product Tags

Hazard Symbols Xi – Irritant
Risk Codes 36/37/38 – Irritating to eyes, respiratory system and skin.
Safety Description S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 – Wear suitable protective clothing.
S37/39 – Wear suitable gloves and eye/face protection
WGK Germany 3
HS Code 29189900
Hazard Note Irritant

 

Introduction

Caffeic acid is an organic acid that occurs naturally in coffee beans and other plants, and it is found in trans and cis isomers. The trans isomer of caffeic acid, also known as the trans form of caffeic acid, has the following properties: Chemical properties: The trans isomer of caffeic acid is a white solid that is relatively stable at room temperature. It is a derivative of polyhydroxyphenylpropionic acid with surface activity and antioxidant properties. Taste and aroma: Caffeic acid trans isomers usually have a sour taste, and excessive organic acid accumulation may have some effect on the mouthfeel. Method: Caffeic acid trans isomers can be extracted by roasting, grinding and other processes of coffee beans. It can also be prepared by chemical synthesis. For individual populations such as pregnant women, infants and other special populations, the intake of caffeic acid trans isomers in the diet should be appropriately controlled.


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