(S)-N-ALPHA-T-BUTYLOXYCARBONYL-PYROGLUTAMIC ACID T-BUTYL ESTER（CAS# 91229-91-3)

Introduction

di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is a compound whose chemical formula is C14H23NO6. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:

-Appearance: di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is a colorless to white crystalline solid.

-Solubility: It is soluble in organic solvents such as ethanol, methanol and dimethyl sulfoxide.

-Melting point: The compound melts at about 104-105°C.

Use:

di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is a commonly used amino acid derivative, often used as a reagent in organic synthesis. It can be used to synthesize biologically active compounds, such as drugs and polymer materials.

Method:

The preparation of di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is usually carried out by the following steps:

1. Dissolve pyroglutamic acid tert-butyl ester in dry dimethyl sulfoxide.

2. An appropriate amount of N,N’-dihydroxyethyl isopropanamide was added and the reaction mixture was cooled to below 0°C.

3. Add di-tert-butyl carbonate slowly while maintaining the temperature of the reaction mixture below 0°C.

4. After completion of the reaction, the reaction mixture was added to water to produce a solid precipitate of di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate.

5. The final product was obtained by the steps of crystallization, filtration and drying.

Safety Information:

di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate should be used and handled in accordance with safe practices to avoid exposure to skin, eyes and inhalation. In addition, it should be stored in a dry, cool place and away from fire and oxidants. For specific safety information, refer to the Chemical Safety Data Sheet (MSDS) or the relevant information provided by the supplier.