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(S)-3-Hydroxy-gamma-butyrolactone(CAS# 7331-52-4)

Chemical Property:

Molecular Formula C4H6O3
Molar Mass 102.09
Density 1.241g/mLat 25°C(lit.)
Melting Point 1.24
Boling Point 98-100°C0.3mm Hg(lit.)
Flash Point >230°F
Water Solubility Miscible with water, alcohol and other organic solvent. Immiscible with light petroleum.
Vapor Presure 5.42E-05mmHg at 25°C
BRN 1280864
pKa 12.87±0.20(Predicted)
Storage Condition Inert atmosphere,2-8°C
Refractive Index n20/D 1.464(lit.)
Physical and Chemical Properties (s)-3-hydroxy-gamma butyrolactone is a colorless liquid, soluble in water, alcohol and other organic solvents, insoluble in petroleum ether, etc., it is a very important organic synthesis intermediates, it is also a very important source of chirality. Mainly used as a key intermediate of Modulator (R)-gamma-hydroxy-beta-Q hydroxybutyric acid [(R)-GABOB],(R)-GABOB is used to treat hyperlipidemia;(s)-Oxiracetam is a promoter of brain metabolism, but also its synthesis; Its reduction can be obtained (s)-3-hydroxytetrahydrofuran, which is an important intermediate for the treatment of AIDS drugs; the (s)-3-hydroxy-4-bromobutyric acid synthesized from it is a potential stabilizer; It is converted into (s)-5-hydroxymethyl-1, 3-oxazolin-2-one available for the latest generation of antibacterial drugs; In addition,(s)-n-methyl-3-hydroxypyrrole and (R)–N-methyl -3-methyl-pyrrole also has important physiological activity, can also be obtained by simple conversion of (s)-3-hydroxy-gamma butyrolactone. Many natural products can also be synthesized from (s)-3-hydroxy-γbutyrolactone.

Product Detail

Product Tags

Hazard Symbols Xi – Irritant
Risk Codes 36/37/38 – Irritating to eyes, respiratory system and skin.
Safety Description S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 – Wear suitable protective clothing.
S37/39 – Wear suitable gloves and eye/face protection
WGK Germany 3
FLUKA BRAND F CODES 3-10
HS Code 29322090

 

Introduction

(S)-3-hydroxy-γ-butyrolactone is an organic compound. It is a colorless liquid with a sweet, fruity taste.

 

There are several methods for the preparation of (S)-3-hydroxy-γ-butyrolactone, which is commonly obtained by catalytic hydrogenation. The specific method is to react an appropriate amount of γ-butyrolactone with a catalyst (such as copper-lead alloy) at an appropriate temperature and pressure, and after catalytic hydrogenation, (S)-3-hydroxy-γ-butyrolactone is obtained.

 

Safety Information: (S)-3-hydroxy-γ-butyrolactone has low toxicity under general use conditions and is not a hazardous chemical. Care should be taken to avoid contact with skin, eyes, and respiratory tract during use. In case of accidental contact, rinse with water and seek medical attention in time. The compound should be kept away from ignition and high temperature environments, and avoid contact with oxidants and acids. In addition, it should be used in accordance with proper operating procedures and safe operating measures.


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