(S)-(-)-1 2-Diaminopropane dihydrochloride（CAS# 19777-66-3)
Risk and Safety
| Risk Codes | R36/37/38 – Irritating to eyes, respiratory system and skin. R23/24/25 – Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29212900 |
(S)-(-)-1 2-Diaminopropane dihydrochloride（CAS# 19777-66-3) Information
| Overview | (S)-(-)-diaminopropane dihydrochloride can be used as a pharmaceutical synthesis intermediate, such as the preparation of Dexrazoxane, it is the dextrorotatory enantiomer of the antitumor drug razoxane. For heart protection drugs, clinical for the Prevention of anthracycline anticancer drugs caused by cardiac toxicity and leukemia in children due to chemotherapy caused by heart damage, often as an adjuvant in the treatment of cancer. |
| Use | (S)-(-)-diaminopropane Dihydrochloride is an organic intermediate, it can be prepared by reacting D-(-)-tartaric acid and propylenediamine. The diamine has been used in the synthesis of chiral imidazoline compounds |
| preparation | preparation of (S)-(-)-diaminopropane dihydrochloride: add 30.0gD-(-)-tartaric acid and 8.0 ml water and g(±)-1, 2-propanediamine in the reaction flask, stir to dissolve, cool, add Dropwise, the temperature was raised to reflux for 2 hours with stirring. The stirring was stopped, and the temperature was raised to 80 ° C. For 1 hour. Then, the temperature was gradually and slowly lowered to room temperature, suction filtered, and vacuum dried to obtain 16.1g of (S)-1, 2-propanediamine ditartrate. Add 16.1g of (S)-1, 2-propanediamine ditartrate and of water to the reaction flask, dissolve with heating, and then add a solution of 7.43g of potassium chloride and 20ml of water, the mixture was stirred at 70 °c for 2 hours. After cooling, the refrigerator was allowed to stand for crystallization. The filtrate was filtered with suction and distilled to dryness under reduced pressure to give 84% G of yellow solid (3), yield 4.02,[α]20D =-°(C = 1%,H2O). |
Write your message here and send it to us
