Nalpha-FMOC-L-Glutamine（CAS# 71989-20-3)
| Hazard Symbols | Xi – Irritant |
| Risk Codes | 36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 – Avoid contact with skin and eyes. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S27 – Take off immediately all contaminated clothing. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
Introduction
Fmoc-Gln-OH(Fmoc-Gln-OH) is an amino acid derivative with the following properties:
Nature:
-Chemical formula: C25H22N2O6
-Molecular weight: 446.46g/mol
-Appearance: White or almost white crystal or powder
-Solubility: Fmoc-Gln-OH is soluble in some organic solvents, such as dimethyl sulfoxide (DMSO) or N,N-dimethylformamide (DMF).
Use:
-Biochemical research: Fmoc-Gln-OH can be used as a protecting group in solid phase synthesis for peptide or protein synthesis.
-Drug Development: Fmoc-Gln-OH can be used as intermediates in the synthesis of drugs or biologically active peptides.
Preparation Method:
The preparation of the Fmoc-Gln-OH can be accomplished by the following steps:
1. First, glutamine is reacted with fluoric anhydride (Fmoc-OSu) to obtain Fmoc-Gln-OH acid fluoride (Fmoc-Gln-OF).
2. Then, the Fmoc-Gln-OF is reacted with pyridine (Py) or N,N-dimethylpyrrolidone (DMAP) under basic conditions to generate Fmoc-Gln-OH.
Safety Information:
-The Fmoc-Gln-OH is generally safe under normal operating conditions, but it is still necessary to comply with laboratory safety procedures.
-Be careful to prevent contact with skin, eyes or mucous membranes, and avoid inhalation or ingestion.
-During use, you can wear appropriate personal protective equipment, such as laboratory gloves, safety glasses and laboratory clothes.
-In case of any accident or discomfort, seek medical help in time and bring detailed information on chemicals for reference.
