N-Methylacetamide（CAS# 79-16-3)
| Hazard Symbols | T – Toxic |
| Risk Codes | 61 – May cause harm to the unborn child |
| Safety Description | S53 – Avoid exposure – obtain special instructions before use. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 2 |
| RTECS | AC5960000 |
| TSCA | Yes |
| HS Code | 29241900 |
| Toxicity | LD50 oral in rat: 5gm/kg |
Introduction
N-Methylacetamide is an organic compound. It is a colorless liquid that is soluble in water and many organic solvents at room temperature.
N-methylacetamide is commonly used in organic synthesis as a solvent and intermediate. N-methylacetamide can also be used as a dehydrating agent, ammoniating agent, and carboxylic acid activator in organic synthesis reactions.
The preparation of N-methylacetamide can generally be obtained by the reaction of acetic acid with methylamine. The specific step is to react acetic acid with methylamine at a molar ratio of 1:1 under appropriate conditions, and then distillation and purification to obtain the target product.
Safety information: The vapor of N-methylacetamide can irritate the eyes and respiratory tract, and has a mild irritating effect when in contact with the skin. When using or handling, personal protective measures should be taken, such as wearing protective glasses, protective gloves, etc. N-methylacetamide is also toxic to the environment, so it is necessary to comply with relevant environmental protection laws and regulations and pay attention to proper disposal of waste. When using and storing, the relevant safety operating procedures and operating guidelines must be followed.
