N-Cbz-L-Leucine（CAS# 2018-66-8)
Risk and Safety
| Hazard Symbols | Xn – Harmful |
| Risk Codes | R10 – Flammable R20/22 – Harmful by inhalation and if swallowed. R37/38 – Irritating to respiratory system and skin. R40 – Limited evidence of a carcinogenic effect R41 – Risk of serious damage to eyes R36/37/38 – Irritating to eyes, respiratory system and skin. R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed. R67 – Vapors may cause drowsiness and dizziness R63 – Possible risk of harm to the unborn child R19 – May form explosive peroxides |
| Safety Description | S16 – Keep away from sources of ignition. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 – Wear suitable protective clothing. S36/37 – Wear suitable protective clothing and gloves. S60 – This material and its container must be disposed of as hazardous waste. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| RTECS | OH2921000 |
| HS Code | 29242990 |
N-Cbz-L-Leucine（CAS# 2018-66-8) introduction
Cbz-L-leucine, the full name of Boc-L-leucine (Boc stands for dibutoxycarbonyl protecting group), is an amino acid derivative. The following is an introduction to its nature, use, manufacturing methods and safety information:
Quality:
- Appearance: White crystalline solid
- Soluble: Soluble in ethanol, dimethylformamide (DMF) and dichloromethane
Use:
- CBZ-L-Leucine is a commonly used amino acid protecting group that protects the hydroxyl group of leucine during the synthesis of peptides to prevent it from reacting with other reactants. In peptide synthesis where multiple leucine residues need to be introduced, Cbz-L-leucine can be used to protect the hydroxyl group of leucine for subsequent synthesis processes.
- Leucine is an important amino acid that plays an important role in protein structure and function.
Method:
- The preparation of Cbz-L-leucine is generally obtained by the reaction of leucine with Boc-OSu (Boc—N-nitrocarbonyl-L-leucine). In the reaction, Boc-OSu acts as an introducer of the protective group and undergoes esterification reaction with leucine to generate Cbz-L-leucine.
Safety Information:
- Cbz-L-leucine is a chemical and should be stored properly away from ignition and oxidants.
- During use, avoid inhaling its dust or coming into contact with the skin and eyes.
- Follow relevant safe practices when handling and storing, and wear appropriate personal protective equipment such as lab gloves and eye protection.
