N-Boc-O-Benzyl-D-serine（CAS# 47173-80-8)
| Hazard Symbols | Xn – Harmful |
| Risk Codes | R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 – Avoid contact with skin and eyes. S36 – Wear suitable protective clothing. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 2924 29 70 |
| Hazard Class | IRRITANT |
Introduction
N-Boc-O-benzyl-D-serine is a compound that has the following properties:
1. Appearance: colorless to yellowish solid.
2. Solubility: Soluble in some organic solvents, such as dimethylformamide (DMF) and dichloromethane.
3. Stability: Stable under dry conditions, but hydrolysis may occur in a humid environment.
One of the main uses of N-Boc-O-benzyl-D-serine is as an intermediate in organic synthesis. It is commonly used in the synthesis of biologically active natural products or drugs, and can be subsequently modified by other reactions.
The preparation of N-Boc-O-benzyl-D-serine can be carried out by the following steps:
1. Benzyl-serine reacts with di-tert-butyldimethylsilyl (Boc) chloride to generate N-Boc-benzyl-serine.
2. This intermediate can be further reacted with benzyl alcohol in dichloromethane to give N-Boc-O-benzyl-D-serine.
Pay attention to safety information when using N-Boc-O-benzyl-D-serine, prevent contact with skin and eyes, and avoid inhalation or intake. At the same time, sealed storage can prolong the stability of the compound.
