N-(9-Fluorenylmethyloxycarbonyl)-N’-trityl-D-asparagine(CAS# 180570-71-2)
Risk and Safety
WGK Germany | 3 |
HS Code | 29242990 |
Hazard Class | IRRITANT |
N-(9-Fluorenylmethyloxycarbonyl)-N’-trityl-D-asparagine(CAS# 180570-71-2) Introduction
2. Use: Fmoc-D-Asn(Trt)-OH is an important reagent used in the field of polymer synthesis and biochemistry. It is commonly used in protecting group strategies in solid phase synthesis to protect amino groups in amino acids or peptide fragments. This protecting group can be removed by hydrofluoric acid under ammonia-alkaline conditions after the synthesis.
3. Preparation method: Fmoc-D-Asn(Trt)-OH preparation method is more complex, generally need to use multi-step reaction. A common synthetic method is to react trityl amine with N-protected D-asparagine, and then perform a deprotection reaction under appropriate conditions to obtain the final product.
4. Safety information: Although Fmoc-D-Asn(Trt)-OH is relatively safe under general experimental conditions, it may cause irritation to the eyes, skin and respiratory tract. Use should follow laboratory practices and use appropriate protective measures such as gloves, goggles and protective clothing. During use and storage, keep away from fire and oxidizing agents, and store in a dry, cool place.