Metomidate（CAS# 5377-20-8)

Introduction

The following is an introduction to the nature, use, manufacturing method, and safety information of Metomidate:

Quality:

1. Appearance: The common form of Metomidate is a white solid.

2. Solubility: It has low solubility in water and is soluble in organic solvents such as methanol and ethanol.

Use:

Metomidate is often used as an animal anesthetic and hypnotic agent. It is a GABA receptor agonist that produces a calming and hypnotic effect by affecting certain pathways in the central nervous system. In veterinary medicine, it is commonly used for anesthesia in fish, amphibians, and reptiles.

Method:

The preparation of Metomidate usually involves the following steps:

1. 3-cyanophenol and 2-methyl-2-propanone are condensed to form an intermediate.

2. The intermediate is reacted with formaldehyde under alkaline conditions to form the precursor of Metomidate.

3. Heating and hydrolysis of the precursor under alkaline conditions to generate the final Metomidate product.

The specific synthesis route can be adjusted according to the specific process and conditions.

Safety Information:

1. Metomidate is an anesthetic and should be used in accordance with the relevant safety protocols.

3. It may have effects on the central nervous system, so careful consideration should be taken when using it to avoid excessive use.

4. Metomidate is a toxic substance and proper chemical management practices should be followed during storage and handling.