Methyl 5-chloro-6-methoxynicotinate（CAS# 220656-93-9)
| Hazard Class | IRRITANT |
Introduction
Methyl 5-chloro-6-methoxynicotinate is an organic compound.
Quality:
- Appearance: Colorless to pale yellow liquid
- Solubility: Soluble in many organic solvents such as ethanol, ether and methylene chloride
Use:
- Methyl 5-chloro-6-methoxynicotinate is an important intermediate compound with a wide range of applications in the research and preparation of bioactive substances.
Method:
Methyl 5-chloro-6-methoxynicotinate can be synthesized by the following steps:
6-Methoxynicotinamide is synthesized by reacting pyridine-3-carboxylic acid with methanol under appropriate conditions.
6-Methoxynicotinamide is reacted with sulfur chloride to form 5-chloro-6-methoxynicotinamide.
Under alkaline conditions, 5-chloro-6-methoxynicotinamide is converted to methyl 5-chloro-6-methoxynicotinate by a methanol esterification reaction.
Safety Information:
Methyl 5-chloro-6-methoxynicotinate is generally safe with proper handling and use, but the following are still important to be aware of:
- This compound can be harmful to the environment and its release into the natural environment should be avoided.
- Appropriate personal protective equipment such as lab gloves, goggles, and protective clothing should be used during handling.
- Avoid direct contact with skin and eyes.
- When storing and using, follow safe chemical handling protocols and keep them away from combustibles and heat sources.
- This compound is restricted to use by professionals or under proper guidance.
