Methoxymethyl triphenylphosphonium chloride（CAS# 4009-98-7)
Introduction
Uses
(Methoxymethyl) triphenylphosphorus chloride is used to synthesize cefaltacin, which is an antiviral and anti-tumor drug. It is also used to synthesize a fragment of paclitaxel.
Preparation
A method for synthesizing (methoxymethyl) triphenylphosphorus chloride, comprising the following steps: under the protection of nitrogen, adding 50mL of anhydrous acetone in a reactor, then adding 32g of triphenylphosphine, stirring and raising the temperature to 37°C, maintaining a constant temperature, adding 20g of methyl chloromethyl ether to the reactor, and then reacting at 37°C for 3h, slowly raising the temperature to 47°C at a rate of 1°C/min, the reaction was continued for 3h, the reaction was stopped, and 37.0g (methoxymethyl) triphenylphosphorus chloride was obtained by filtration, anhydric ether washing and drying with a yield of 88.5%.
