Metadoxine（CAS# 74536-44-0)

Chemical Property:

Molecular Formula	C8H11NO3.C5H7NO3
Molar Mass	298.293
Melting Point	102-104°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White to Light Yellow
Storage Condition	Sealed in dry,2-8°C
Use	Determination of content by HPLC
In vitro study	Simultaneous Metadoxine treatment notably inhibits adipogenic differentiation in a dose-dependent manner. Metadoxine treatment from day 4 through day 8 is required for inhibition of MDI-induced preadipocyte differentiation. Metadoxine prevents glutathione depletion and the increase in lipid peroxidation damage caused by ethanol and acetaldehyde in HepG2 cells. In hepatic stellate cells, Metadoxine prevents the increase in collagen and attenuated TNF-α secretion caused by acetaldehyde. Thus, Metadoxine could be useful in preventing the damage produced in early stages of alcoholic liver disease as it prevents the redox imbalance of the hepatocytes and prevents TNF-α induction, one of the earliest events in hepatic damage.

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Introduction

Metadoxin, chemically known as N,N-dimethylformamide, is a colorless liquid. Its properties are as follows:

Physical properties: Metadoxine is a colorless liquid with a pungent odor, volatile at room temperature, miscible with water and most common organic solvents.

Chemical properties: Metadoxine is a highly reducing compound that can be hydrolyzed by sodium hydroxide or sodium carbonate solutions to form formamide and methanol.

Use of metaxacin:

Catalyst: Metadoxine can be used as a carrier for metal catalysts, and is used to catalyze the formylation reaction of amines in organic synthesis.

Solvents: Metadoxine is widely used as a solvent in organic synthesis, such as dissolving metal complexes, polymers, and intermediates for catalytic reactions.

Preparation method: The preparation of metadoxine is generally obtained by the reaction of formamidine and formic acid.

Safety information: Metaxacin is irritating and corrosive, and has an irritating effect on the skin, eyes and mucous membranes. Care should be taken to avoid direct contact with skin and eyes, and protective gloves and goggles should be worn if necessary. Attention should be paid to ventilation during use to avoid inhaling its vapors. Meltadoxine is a combustible substance and should be kept away from open flames and high temperature sources.

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