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Levodopa(CAS# 59-92-7)

Chemical Property:

Molecular Formula C9H11NO4
Molar Mass 197.19
Density 1.3075 (rough estimate)
Melting Point 276-278 °C (lit.)
Boling Point 334.28°C (rough estimate)
Specific Rotation(α) -11.7 º (c=5.3, 1N HCl)
Flash Point 225°C
Water Solubility Slightly soluble in water, dilute hydrochloric acid and formic acid. Insoluble in ethanol.
Solubility Easily soluble in dilute hydrochloric acid and formic acid, soluble in water, insoluble in ethanol, benzene, chloroform and ethyl acetate
Vapor Presure 7.97E-09mmHg at 25°C
Appearance White to milky white crystalline powder
Color White to creamy
Merck 14,5464
BRN 2215169
pKa 2.32(at 25℃)
Storage Condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents. Light and air sensitive.
Sensitive Sensitive to light and air
Refractive Index -12 ° (C=5, 1mol/L H
MDL MFCD00002598
Physical and Chemical Properties melting point 295°C
specific optical rotation -11.7 ° (c = 5.3, 1N HCl)
Use An effective drug for the treatment of paralysis of shock, mainly used for Parkinson’s syndrome, etc

Product Detail

Product Tags

Hazard Symbols Xn – Harmful
Risk Codes R22 – Harmful if swallowed
R36/37/38 – Irritating to eyes, respiratory system and skin.
R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed.
Safety Description S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 – Wear suitable protective clothing.
S24/25 – Avoid contact with skin and eyes.
WGK Germany 3
RTECS AY5600000
FLUKA BRAND F CODES 10-23
TSCA Yes
HS Code 29225090
Toxicity LD50 in mice (mg/kg): 3650 ±327 orally, 1140 ±66 i.p., 450 ±42 i.v., >400 s.c.; in male, female rats (mg/kg): >3000, >3000 orally; 624, 663 i.p.; >1500, >1500 s.c. (Clark)

 

Introduction

Pharmacological effects: anti-tremor paralysis drugs. It enters the brain tissue through the blood-brain barrier, and is decarboxylated by dopa decarboxylase and converted into dopamine, which plays a role. It is used for primary tremor paralysis and non-drug-induced tremor paralysis syndrome. It has good effect on moderate and mild, severe or poor elderly.


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