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Hyaluronidase(CAS#9001-54-1) Featured Image
  • Hyaluronidase(CAS#9001-54-1) 1

Hyaluronidase(CAS#9001-54-1)

Chemical Property:

Molecular Formula C18H14O7
Molar Mass 342.29956
Appearance Morphological lyophilized powder
Color white to slightly brown
Merck 13,4777
Storage Condition −20°C
Physical and Chemical Properties White or light yellow flocculent freeze-dried, odorless, soluble in water, insoluble in ethanol, acetone and ether, the optimum pH value of 4.5-6.0. Stability: The freeze-dried material stored at 4 ℃ for one year showed no significant decrease in vitality; Under the condition of 42 ℃, the activity was unchanged by heating for 60min; 100 ℃ for 5min to retain 80% of the vitality; Low concentration aqueous solution is easy to be inactivated, the addition of NaCl can increase its stability; It is easy to deteriorate when exposed to heat. Inhibitors of heavy metal ions (Cu2 +, HR<2 +, Fe<3 +, Mn<2 +, Zn<2 +), acidic organic dyes, bile salts, polyanions and high molecular weight polysaccharides such as chondroitin sulfate B, heparin, heparan sulfate; Activators are polycations. The absorption coefficient of 1% aqueous solution at 280nm was 8. Hyaluronidase is mainly the hydrolysis of hyaluronic acid in N-acetyl-beta-D-glucosamine and D-glucuronic acid between the beta -1,4-bond, resulting in four sugar residues, do not release monosaccharides, enzyme reaction: hyaluronic acid + H2O oligo-oligosaccharides.
Use It is used in biochemical research, and is commonly used in clinical practice to promote the dissipation of local edema or hematoma after surgery and trauma, promote the infiltration of local anesthetics, reduce the pain at the injection site, and accelerate the absorption of subcutaneous and intramuscular injection, can also be used for intestinal adhesions.

Product Detail

Product Tags

Safety Description S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
WGK Germany 3
FLUKA BRAND F CODES 3-10
HS Code 35079090

 

 

Hyaluronidase(CAS#9001-54-1)

use
Proteolytic enzymes. It can accelerate the absorption of subcutaneous and intramuscular injection, promote the infiltration of local anesthetics, reduce pain at the injection site, and promote the dissipation of local edema or hematoma after surgery and trauma. It can also be used for intestinal adhesions.
Usage and dosage: subcutaneous or intramuscular injection, 150~15 00 units/time, 1 time/1~2 days, dissolved with normal saline or water for injection first, and then mixed with other injections; Subcutaneous infusion, add 150 units of this product to lOOOmL large infusion.
Preparation hyaluronidase for injection.
security
mouse was injected subcutaneously with LD50>250,000 units/kg; Mice, intramuscular injection of LD50 >1. 250,000 units/kg. It is contraindicated on the site of infection to prevent spread; Cannot be injected intravenously; Ready-to-use. Sometimes allergic reactions may occur, and a skin test should be done before use. Salicylic acid can inhibit the action of this product.
Keep tightly closed and store in a cool, dry place.

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