| Physical and Chemical Properties |
White or light yellow flocculent freeze-dried, odorless, soluble in water, insoluble in ethanol, acetone and ether, the optimum pH value of 4.5-6.0. Stability: The freeze-dried material stored at 4 ℃ for one year showed no significant decrease in vitality; Under the condition of 42 ℃, the activity was unchanged by heating for 60min; 100 ℃ for 5min to retain 80% of the vitality; Low concentration aqueous solution is easy to be inactivated, the addition of NaCl can increase its stability; It is easy to deteriorate when exposed to heat. Inhibitors of heavy metal ions (Cu2 +, HR<2 +, Fe<3 +, Mn<2 +, Zn<2 +), acidic organic dyes, bile salts, polyanions and high molecular weight polysaccharides such as chondroitin sulfate B, heparin, heparan sulfate; Activators are polycations. The absorption coefficient of 1% aqueous solution at 280nm was 8. Hyaluronidase is mainly the hydrolysis of hyaluronic acid in N-acetyl-beta-D-glucosamine and D-glucuronic acid between the beta -1,4-bond, resulting in four sugar residues, do not release monosaccharides, enzyme reaction: hyaluronic acid + H2O oligo-oligosaccharides. |
| Use |
It is used in biochemical research, and is commonly used in clinical practice to promote the dissipation of local edema or hematoma after surgery and trauma, promote the infiltration of local anesthetics, reduce the pain at the injection site, and accelerate the absorption of subcutaneous and intramuscular injection, can also be used for intestinal adhesions. |
