Fmoc-S-3-amino-2-hydroxymethyl-propanoic-acid （CAS#1217768-32-5 )
Fmoc-S-3-amino-2-hydroxymethyl-propanoic-acid （CAS#1217768-32-5 )
Chemical Properties: The compound contains functional groups such as carboxyl, amino, hydroxymethyl, and FMOC protective groups. The carboxyl group is acidic, can neutralize with alkali, and can also undergo esterification reaction with alcohol; The amino group is alkaline, can react with acid to form salt, and can also participate in reactions such as amidation; Hydroxymethyl group can undergo characteristic reactions of hydroxyl groups, such as being oxidized to aldehyde groups or carboxyl groups, or participating in etherification, esterification and other reactions; The FMOC protecting group can be removed under certain conditions for further reaction or synthesis.
Application field: In organic synthesis, especially peptide synthesis, it is often used as an important intermediate for the construction of polypeptide molecules with specific structures and functions. Using its functional groups such as amino group, carboxyl group, and hydroxymethyl group, different amino acids or other organic fragments can be linked through a series of chemical reactions to synthesize peptide compounds with specific sequences and functions.
Synthesis method: Generally, it can be synthesized by using amino acids with suitable protecting groups as starting materials, introducing FMOC protecting groups through reaction with reagents such as Fmoc-Cl, and then modifying and transforming other functional groups. It can also be prepared from some compounds containing hydroxymethyl and amino groups by stepwise construction of carboxyl groups and the introduction of FMOC protective groups.
