Fmoc-O-tert-butyl-L-tyrosine（CAS# 71989-38-3)
| Hazard Symbols | Xi – Irritant |
| Risk Codes | 36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 – Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2924 29 70 |
Introduction
Fluorene methoxycarbonyl-oxotert-butyl-tyrosine is a chemical compound often abbreviated as FMOC-Tyr(tBu)-OH. The following is an introduction to its nature, use, preparation and safety information:
Quality:
- Appearance: White or off-white solid.
- Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide and dimethylformamide.
Use:
- Protecting groups in chemical synthesis: FMOC groups can be used to protect amino groups in phenolic compounds to prevent them from reacting. FMOC-Tyr(tBu)-OH can be used as a starting material for the preparation of peptide chains in chemical synthesis.
Method:
The preparation method of FMOC-Tyr(tBu)-OH can be achieved by the following steps:
- Fluorenyl chloride (FMOC-Cl) is reacted with tert-butyl (tBu-NH2) to give fluorenylmethoxycarbonyl-tert-butichsyl (FMOC-tBu-NH-).
- Then, react the resulting FMOC-tBu-NH- with tyrosine (Tyr-OH) to generate FMOC-Tyr(tBu)-OH.
Safety Information:
- The use of FMOC-Tyr (tBu)-OH is subject to compliance with laboratory safety protocols.
- Avoid contact with skin and eyes, and wear protective gloves and goggles when using.
- Use in a well-ventilated area, away from fire and combustibles.
- It must not be released into the environment and should be handled and disposed of in accordance with local regulations.
