FMOC-O-tert-Butyl-L-serine（CAS# 71989-33-8)

Introduction

FMOC-O-tert-butyl-L-serine is an organic compound, and its chemical name is epichlorotoluene serine. The following is an introduction to its properties, uses, manufacturing methods and safety information:

Quality:

FMOC-O-tert-butyl-L-serine is a solid with a white to off-white appearance. It decomposes in solution and is susceptible to moisture.

Use:

FMOC-O-tert-butyl-L-serine is a commonly used aminoprotective group that is widely used in the synthesis of peptides and proteins. Its main use is as a protective group of peptide chains, by protecting amino groups during synthesis and avoiding their reaction with other functional groups. It also has good solubility and can be used as a synthetic intermediate.

Method:

The preparation of FMOC-O-tert-butyl-L-serine typically uses the FMOC protection strategy combined with the Wick reaction. Tert-butoxycarbonyl methylserine is reacted with triethylamine and tetraethyl disilicate to form FMOC-O-tert-butyl-L-serine. The specific synthesis method needs to be performed under suitable laboratory conditions.

Safety Information:

The use of FMOC-O-tert-butyl-L-serine should follow safe practices. It may have an irritating effect on the eyes, skin, and respiratory tract in its pure form. Appropriate protective equipment such as gloves, safety goggles, and respiratory protective equipment should be worn when in use. It should be kept away from open flames and heat sources and operated in a well-ventilated area. If ingested or inhaled, seek medical attention immediately.