Fmoc-L-homophenylalanine (CAS# 132684-59-4)
Risk and Safety
| Hazard Symbols | Xi – Irritant |
| Risk Codes | 36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. S44 - S35 – This material and its container must be disposed of in a safe way. S28 – After contact with skin, wash immediately with plenty of soap-suds. S7 – Keep container tightly closed. S4 – Keep away from living quarters. |
| WGK Germany | 3 |
| HS Code | 2924 29 70 |
| Hazard Class | IRRITANT |
Introduction
2. Solubility: Soluble in organic solvents such as dimethyl sulfoxide (DMSO) and ethyl acetate (EtOAc), insoluble in water.
3. molecular formula: C32H29NO4.
4. molecular weight: 495.58.
The main use of Fmoc-L-homophenylalanine is as a protecting group in peptide synthesis. Fmoc is an abbreviation for furoyl and its derivatives, which can protect the amino group in amino acids. When it is desired to synthesize the peptide chain, the amino group can be made available for the reaction by removing the Fmoc protecting group. Therefore, Fmoc-L-homophenylalanine plays an important role in the preparation of peptide drugs and related bioactive molecules.
The preparation method of Fmoc-L-homophenylalanine is relatively complicated and involves a multi-step synthesis reaction. A common preparation method is by co-reacting Fmoc-protected phenylalanine with other reagents, such as silver azide formate (AgNO2), followed by trifluoroacetic acid treatment to give Fmoc-L-homophenylalanine.
The following safety information should be noted when using Fmoc-L-homophenylalanine:
1. avoid direct contact with skin, eyes and mucous membranes, because it may be irritating to the human body.
2. Storage should avoid contact with strong oxidants or strong acids to prevent dangerous reactions.
3. Use appropriate personal protective equipment such as gloves, protective glasses and laboratory coats during use and handling.
4. All operations should be carried out under well-ventilated laboratory conditions.
In summary, Fmoc-L-homophenylalanine is an amino acid protecting group commonly used in peptide synthesis and has a wide range of applications. When using and handling the compound, it is necessary to pay attention to safe handling and storage.
