Fmoc-L-glutamic acid-gamma-benzyl ester (CAS# 123639-61-2)

Fluorene methoxycarbonyl-L-glutamic acid-Γ-benzyl is an organic compound used in peptide synthesis in solid-phase synthesis. Its nature:
- Appearance: White to pale yellow solid
- Solubility: Fmoc-L-Glu(OtBu)-OH has good solubility among common organic solvents.

The main use of Fmoc-L-Glu (OtBu)-OH is as a protecting group in peptide synthesis. When synthesizing peptide chains, Fmoc-L-Glu(OtBu)-OH binds to amino acids, protecting their activity against non-specific reactions with other reactants. After the reaction is completed, Fmoc-L-Glu(OtBu)-OH can be removed by removing the protecting group to restore the activity of amino acids.

The preparation of Fmoc-L-Glu(OtBu)-OH is relatively complex and generally requires the use of a series of organic synthesis steps. Glutamic acid is reacted with bromoacetate to obtain ethyl glutamate. Then, ethyl glutamate is reacted with benzyl alcohol to form ethyl glutamate benzyl alcohol ester. Ethyl glutamate benzyl alcohol ester was reacted with Fmoc-Cl to generate the target product Fmoc-L-Glu(OtBu)-OH.

Safety Information: Fmoc-L-Glu(OtBu)-OH is a laboratory drug and needs to be used under safe laboratory operation. Follow general laboratory safety practices, including wearing personal protective equipment (e.g., lab gloves, goggles, etc.), avoiding skin contact and inhalation, and operating in a well-ventilated laboratory. The compound should be stored in an airtight container, away from ignition and oxidants.