Fmoc-L-Glutamic acid 1-tert-butyl ester（CAS# 84793-07-7)

Introduction

Fluorene methoxycarbonyl-L-glutamate-1-tert-butyl ester, also known as Fmoc-L-glutamic acid-1-tert-butyl ester, is an organic compound commonly used in peptide synthesis and solid-phase synthesis in organic synthesis.

Quality:

Fluorene methoxycarbonyl-L-glutamic acid-1-tert-butyl is a solid with white to yellowish crystals. It has low solubility in water but good solubility in organic solvents such as dimethyl sulfoxide or methanol.

Use:

Fluorene methoxycarbonyl-L-glutamic acid-1-tert-butyl is a commonly used protective amino acid in peptide synthesis. It can be used to protect the group through the reaction, so that it is exposed in the synthesis and further peptide chain extension. This compound is particularly suitable for solid-phase synthesis, where peptide chains are conjugated to protective amino acids on resin branches.

Method:

The preparation of fluorene methoxycarbonyl-L-glutamic acid-1-tert-butyl is usually achieved by chemical synthesis. Fluorene methanol is first synthesized into fluorene carboxyl chloride through chemical reaction, then reacted with L-glutamic acid to form fluorene methoxycarbonyl-L-glutamic acid, and finally reacted with tert-butanol to form the final product.

Safety Information:

Fluorene methoxycarbonyl-L-glutamic acid-1-tert-butyl is generally considered to have no obvious toxicity to humans under normal experimental conditions. Relevant laboratory safety protocols need to be followed during handling, including wearing protective gloves and glasses, and operating in well-ventilated conditions.