Fmoc-L-Aspartic acid-1-benzyl ester（CAS# 86060-83-5)

Introduction

Fmoc-Asp-OBzl(Fmoc-Asp-OBzl) is a compound mainly used in peptide synthesis and solid phase synthesis.

Nature:

Fmoc-Asp-OBzl is a white crystalline solid with good solubility and stability. Its chemical formula is C33H29NO7 and its molecular weight is 555.6. It has a fluorenyl protecting group (Fmoc) and a benzoyl protecting group (Bzl) to protect the aspartic acid.

Use:

Fmoc-Asp-OBzl as a protecting group can be used in the synthesis of peptides and proteins. It can be applied to the solid phase synthesis technique and the protecting group removal step in the peptide synthesis reaction. In synthesis, the aspartic acid residue may Fmoc-Asp-OBzl be protected in the resulting peptide fragment to prevent unwanted reactions.

Preparation Method:

The preparation of Fmoc-Asp-OBzl is generally accomplished by chemical synthesis. Specifically, Fmoc-Asp-OBzl can be obtained by reacting fluorenecyl chloride (Fmoc-Cl) with aspartic acid -1-benzyl ester (Asp-OBzl).

Safety Information:

Fmoc-Asp-OBzl is a chemical that needs to be handled in the laboratory. Follow relevant laboratory safety procedures during handling, such as wearing appropriate protective equipment (such as gloves, glasses, and laboratory coats) to avoid contact with skin, eyes, and respiratory tract. In addition, it should be stored in a dry, cool place, and away from fire and flammable materials. When using Fmoc-Asp-OBzl, attention should be paid to its toxicity and irritation, and ensure that it is operated in a safe environment.