fmoc-L-4-hydroxyproline（CAS# 88050-17-3)
| Safety Description | S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
Introduction
Fmoc-L-hydroxyproline (Fmoc-Hyp-OH) is an amino acid derivative with the following properties and uses:
Quality:
- Appearance: White or off-white crystalline powder
- Solubility: Soluble in organic solvents such as DMF, DMSO and methanol
- pKa value: 2.76
Use:
- Fmoc-Hyp-OH is mainly used for peptide synthesis and peptide synthesis in solid-phase synthesis
- It acts as part of a protecting group to protect the side chain functional groups of amino acids during solid-phase synthesis to avoid unexpected reactions and maintain selectivity
Method:
Fmoc-Hyp-OH can be prepared by reacting Fmoc-amino acids with L-hydroxyproline in a suitable solvent. Reaction conditions typically include a suitable reaction temperature and a suitable base catalyst, such as N,N-dimethylpyrrolidone (DMAP). The resulting product is purified by steps such as precipitation, washing, and drying.
Safety Information:
- FMOC-HYP-OH is an organic compound and should be handled in accordance with laboratory safety protocols.
- The dust can be inhaled and come into contact with the skin, so care should be taken to avoid direct inhalation or contact.
- During the procedure, appropriate personal protective equipment such as laboratory gloves, eye protection, protective clothing, etc. should be worn.
- It should be stored tightly sealed in a dry, cool place, away from fire and flammable substances.
