Fmoc-L-2-Aminobutyric acid (CAS# 135112-27-5 )
Risk and Safety
| Safety Description | S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2924 29 70 |
| Hazard Class | IRRITANT |
Fmoc-L-2-Aminobutyric acid (CAS# 135112-27-5 )Introduction
L-2-(fluorenylmethoxycarbonylamino) butyric acid, also known as Fmoc-glutamic acid (L-2-(9-fluorenylmethoxycarbonylamino) butyric acid), is an organic substance. The following is a description of some of its properties, uses, methods and safety information:
Nature:
-Appearance: Colorless or slightly yellow crystalline powder;
-Molecular formula: C26H23NO4;
-Molecular weight: 413.47g/mol;
-melting point: about 166-168 ℃;
-Solubility: Fmoc-glutamic acid is soluble in organic solvents such as dimethylformamide and hydrofluoric acid.
Use:
Fmoc-glutamic acid, as a protecting group compound, is often used in peptide synthesis, especially in the synthesis of stable peptide sequences and the synthesis of Levenstein peptides (Levenshtein peptide). It can be used as a synthetic intermediate of amino acids, or used in solid phase synthesis, high performance liquid chromatography, etc.
Preparation Method:
The preparation of Fmoc-glutamic acid generally includes the following steps:
1. In an anhydrous system, L-glutamic acid is reacted with Fmoc-OSu (fluorenylmethoxycarbonyl-chloro anhydride), and sodium chloride (NaCl) is used to promote the reaction to generate Fmoc-glutamic acid Fmoc-A salt.
2. For the Fmoc-glutamic acid salt, it is dissolved in a solvent (such as dimethylformamide) and subjected to an appropriate purification method (such as crystallization) to obtain Fmoc-glutamic acid.
Safety Information:
Fmoc-glutamic acid is generally relatively stable and low toxic under routine operation. But as an organic compound, still need to pay attention to the following safety measures:
-Avoid inhaling dust, contact with skin and eyes;
-During operation, wear protective gloves, glasses and protective clothing that meet safety requirements;
-Operate in a well-ventilated environment to avoid direct exposure for a long time;
-If waste from this compound is to be disposed of, it should be properly disposed of in accordance with local regulations.
Nature:
-Appearance: Colorless or slightly yellow crystalline powder;
-Molecular formula: C26H23NO4;
-Molecular weight: 413.47g/mol;
-melting point: about 166-168 ℃;
-Solubility: Fmoc-glutamic acid is soluble in organic solvents such as dimethylformamide and hydrofluoric acid.
Use:
Fmoc-glutamic acid, as a protecting group compound, is often used in peptide synthesis, especially in the synthesis of stable peptide sequences and the synthesis of Levenstein peptides (Levenshtein peptide). It can be used as a synthetic intermediate of amino acids, or used in solid phase synthesis, high performance liquid chromatography, etc.
Preparation Method:
The preparation of Fmoc-glutamic acid generally includes the following steps:
1. In an anhydrous system, L-glutamic acid is reacted with Fmoc-OSu (fluorenylmethoxycarbonyl-chloro anhydride), and sodium chloride (NaCl) is used to promote the reaction to generate Fmoc-glutamic acid Fmoc-A salt.
2. For the Fmoc-glutamic acid salt, it is dissolved in a solvent (such as dimethylformamide) and subjected to an appropriate purification method (such as crystallization) to obtain Fmoc-glutamic acid.
Safety Information:
Fmoc-glutamic acid is generally relatively stable and low toxic under routine operation. But as an organic compound, still need to pay attention to the following safety measures:
-Avoid inhaling dust, contact with skin and eyes;
-During operation, wear protective gloves, glasses and protective clothing that meet safety requirements;
-Operate in a well-ventilated environment to avoid direct exposure for a long time;
-If waste from this compound is to be disposed of, it should be properly disposed of in accordance with local regulations.
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