Fmoc-D-Cyclohexyl glycine（CAS# 198543-96-3)
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Fmoc-D-Cyclohexyl glycine（CAS# 198543-96-3) Information
| Use |
Fluorene methoxycarbonyl D-cyclohexylglycine is a common pharmaceutical and chemical intermediate, fluorenyl chloride (FMOC-Cl) is a chloroformate. It is used to form fluorene methoxycarbonyl (FMOC group) into fluorene methoxycarbonyl carbamate FMOC carbamate, which is a common amino protecting group. |
| Preparation |
The synthesis of fluorene methoxycarbonyl D-cyclohexylglycine has been reported in the literature. Using cyclohexyl bromide as the raw material, in the presence of sodium alkoxide, it undergoes a alkylation reaction with diethyl malonate, and then hydrolyzes, acidifies, and decarboxylates to obtain cyclohexyl acetic acid; the latter is then brominated and ammonolysis DL-Cyclohexylglycine; finally, acylation reaction occurs in the presence of fluorene methoxycarbonyl chloride to obtain fluorene methoxycarbonyl D-cyclohexylglycine [1]. The synthesis reaction route is as follows: |
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