Fmoc-2-Amino-2-methylpropionic acid（CAS# 94744-50-0)
| Safety Description | S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
Introduction
Fmoc-2-aminoisobutyric acid, also known as Fmoc-Aib, is an organic compound. The following is a detailed introduction to some of the properties, uses, preparation methods and safety information of Fmoc-2-aminoisobutyric acid:
Quality:
Fmoc-2-aminoisobutyric acid is a white crystalline solid with a peculiar odor. It is stable at room temperature and insoluble in water, but soluble in organic solvents such as methanol and methylene chloride.
Use:
Fmoc-2-aminoisobutyric acid is a commonly used protective group in organic synthesis. It can be used as a group for temporary protection of amino groups in synthetic polypeptides and proteins to prevent them from side reactions in chemical reactions.
Method:
The preparation method of FMOC-2-aminoisobutyric acid is generally by chemical synthesis. This is usually done by the reaction of 2-aminoisobutyric acid with Fmoc-OSu (Fmoc-N-hydroxysuccinimidyl) or Fmoc-OXy (Fmoc-N-hydroxysuccinimidate). The reaction is usually carried out at room temperature and purified by solvent extraction and crystallization.
Safety Information:
FMOC-2-aminoisobutyric acid is generally relatively safe under normal conditions of use. As an organic compound, it may pose certain risks to human health. Care should be taken to avoid inhaling powders or solutions while avoiding contact with skin and eyes. Protective gloves, glasses, and masks should be worn when necessary. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical attention. It should be stored in a dry, cool place, away from fire and oxidants.
