Fluprostenol（CAS#40666-16-8）

Fluprostenol（CAS#40666-16-8）

Physicochemical properties

Appearance: colorless oily liquid.
Boiling Point: approx. 608.0 ± 55.0 °C (predicted). The actual boiling point may vary depending on factors such as environmental pressure.
Density: 1.335. This density indicates its solubility and dispersion characteristics in some common organic solvents.
Melting Point: There is no clear public data.
Flash Point: 321.5 °C. This value means that at this temperature, if an ignition source is present, a flash flash may occur when the fluprostol vapor mixes with the air.
Solubility: Soluble in ethanol, e.g. 1mg/100μl in ethanol. Solubility in other organic solvents and water can also have an impact on its practical application.
LogP:3.56040, reflecting its strong lipophilicity, which is conducive to passing through biofilms, and is of great significance in the absorption, distribution and metabolism in vivo.
PSA: 107.22000, that is, polar surface area, has an important impact on its water solubility, biological activity, and interaction with biological macromolecules.
Refractive index: 1.575. This value can be used to identify and analyze the purity and structural characteristics of fluprostol.
Fields of application
Veterinary medicine: as a potent prostaglandin F (FP) receptor agonist, used in livestock breeding to control the reproductive cycle of animals. For example, it can induce female animals to estrus at the same time, so that the herd can estrus and breed at a relatively concentrated time, which is convenient for large-scale breeding management and improves reproductive efficiency; It can also be used to treat long-lasting luteal corpus, pyometra and other reproductive disorders in female animals, and help female animals restore normal reproductive function.
Pharmaceutical: The ophthalmic solution of its isopropyl ester prodrug travoprost (Travoprost) is used as a topical drug to control the progression of open-angle glaucoma and ocular hypertension, protect the optic nerve and visual field by reducing intraocular pressure, and reduce the risk of vision damage caused by glaucoma. In obstetrics and gynecology, fluprostol also has the potential to be used for labor induction, miscarriage, etc., but it is necessary to strictly follow medical norms and safety guidelines.