Ethyl L-pyroglutamate（CAS# 7149-65-7)

Molecular Formula	C7H11NO3
Molar Mass	157.17
Density	1.2483 (rough estimate)
Melting Point	54-56°C
Boling Point	176°C12mm Hg(lit.)
Specific Rotation(α)	-3.5 º (c=5, water)
Flash Point	>230°F
Appearance	Low Melting Solid
Color	White to cream
BRN	82621
pKa	14.78±0.40(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.4310 (estimate)
MDL	MFCD00064497

Product Detail

Hazard Symbols	Xi – Irritant
Risk Codes	36/37/38 – Irritating to eyes, respiratory system and skin.
Safety Description	S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing. S37/39 – Wear suitable gloves and eye/face protection
WGK Germany	3
FLUKA BRAND F CODES	3-10
HS Code	29339900

Introduction	ethyl L-pyroglutamate is a white to cream colored, low melting solid that is a non-natural amino acid derivative, unnatural Amino acids have been used in bacteria, yeast and mammalian cells for protein modification, which have been applied in basic research and drug development, biological engineering and other fields, it is widely used to detect protein structural changes, drug coupling, biosensors and so on.
Use	ethyl L-pyroglutamate can be used as pharmaceutically active molecules and intermediates in organic synthesis, for example, synthetic biologically active molecules such as HIV integrase inhibitors. In the synthetic conversion, the nitrogen atom in the amide group may be coupled with iodobenzene, and the hydrogen on the nitrogen atom may be converted into a chlorine atom. In addition, the ester group may be converted into an amide product by a urethane exchange reaction.
synthetic method	add L-pyroglutamic acid (5.00g), P-toluenesulfonic acid monohydrate (369 mg, 1.94 mmol) and ethanol (100 mL) were stirred overnight at room temperature, the residue was dissolved in 500 EtOAc, the solution was stirred with potassium carbonate and (after filtration), the organic layer was dried over MgSO4, and the organic phase was concentrated in vacuo to give ethyl L-pyroglutamate. Figure 1 synthesis of ethyl L-pyroglutamate