Ethyl 2-bromopyridine-4-carboxylate（CAS# 89978-52-9)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| Hazard Class | IRRITANT |
Introduction
Ethyl 2-bromopyridine-4-carboxylate is an organic compound with the following properties:
Quality:
- Appearance: Colorless to pale yellow liquid
- Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and ether
Use:
Method:
Ethyl 2-bromopyridine-4-carboxylate can be prepared by the reaction of 2-bromopyridine with acetic anhydride.
Safety Information:
- Ethyl 2-bromopyridine-4-carboxylate may be irritating and corrosive to the skin, eyes, and mucous membranes, and requires protective equipment when handling.
- Inhalation of vapours should be avoided and a well-ventilated environment should be maintained.
- Keep away from fire and open flames and keep in a dry, cool place.
- Care should be taken to follow safe chemical operating procedures during use and handling.
Application
Ethyl 2-bromoisonicotinate (ethyl 2-bromopyridine-4-carboxylate, CAS 89978-52-9) is a versatile halogenated pyridine building block widely used as a pharmaceutical intermediate and research chemical. The bromine atom at the 2-position enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl substituents, while the ethyl ester provides a handle for hydrolysis to the carboxylic acid or reduction to the alcohol. This scaffold is a key intermediate for the synthesis of Ivosidenib (a mutant IDH1 inhibitor for acute myeloid leukemia) and other therapeutically active compounds. It is also employed in the preparation of plasma kallikrein inhibitors, isonicotinamide derivatives, and various drug candidates targeting cancer, inflammation, and infectious diseases. As a heterocyclic organic building block, it facilitates rapid structure-activity relationship (SAR) studies and library construction in drug discovery. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity Ethyl 2-bromoisonicotinate with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
