Ethyl 1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo[3 4-c]pyridine-3-carboxylate（CAS# 503615-07-4)

Introduction

The following is an introduction to the properties, uses, preparation methods and safety information of apixaban intermediate 3:

Quality:

Apixaban intermediate 3 is an organic compound. It is solid and soluble in organic solvents such as ether and ethyl acetate.

Uses: It is commonly used for surgical anesthesia and the treatment of severe pain.

Method:

The preparation method of apixaban intermediate 3 can be carried out by the following steps: p-nitrobenzoic acid is reacted with hypobutylthiourea in the co-presence of acetic acid and thionyl chloride to obtain N-(p-nitrophenyl)-N-(hypobutylthioylurea) formic acid, and then, reacted with sodium hydroxide in sodium oxide and methanol solution to obtain apixaban intermediate 3.

Safety Information: Strict safety operating procedures need to be followed when using and handling this compound. Direct contact or inhalation can cause serious harm to human health. Its specific safety information should be evaluated and processed in accordance with relevant regulations and guidelines to ensure safe use and handling. When performing chemical synthesis experiments, they should be operated under appropriate laboratory conditions and personal protective equipment such as chemical goggles, protective gloves, and protective clothing should be used.