Dolutegravir(CAS#1051375-16-6)

Chemical Property:

Molecular Formula	C20H19F2N3O5
Molar Mass	419.38
Density	1.53
Melting Point	187-189°C
Boling Point	669.0±55.0 °C(Predicted)
Solubility	DMSO 84 mg/mL, water <1 mg/mL, ethanol <1 mg/mL
Appearance	White or yellowish solid
Color	White to Pale Beige
pKa	4.50±1.00(Predicted)
Storage Condition	Refrigerator
MDL	MFCD20488027
Use	This product is for scientific research only and shall not be used for other purposes.
In vitro study	S/GSK1349572 showed potent inhibitory effects against nine clinical isolates from patients infected with integrase inhibitor-natural HIV-2, with EC50 ranging from 0.2 nM to 1.4 nM. In Vitro, S/GSK1349572 inhibited strand transfer catalyzed by recombinant HIV-1 integrase with an IC50 of 2.7 nM. In addition, S/GSK1349572 effectively inhibits HIV replication in cells, such as peripheral blood mononuclear cells (PBMCs),MT-4 cells and CIP4 cells infected with self-inactivated PHIV lentiviral vectors, the EC50 was 0.51 nM,0.71 nM and 2.2 nM, respectively. In Vitro, S/GSK1349572 exhibited potent activity against five different non-nucleoside retroviral inhibitor resistant viruses, or nucleoside retroviral inhibitor resistant viruses, with an EC50 range of 1.3 nM -2.1 nM. Similar to the wild-type virus, S/GSK1349572 showed the same activity against both protease inhibitor resistant viruses with EC50 of 0.36 nM and 0.37 nM.

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Dolutegravir(CAS#1051375-16-6)

introduce
S/GSK1349572 (GSK1349572) is an HIV integrase inhibitor with an IC50 of 2.7 nM, moderately potent against the significant anti-Raltegravir mutants Y143R, Q148K, N155H, and G140S/Q148H.
Brief introduction
Dulutgravir. It is a natural vegetable oil extracted from evening primrose seeds.

Dulutgravir is a polyunsaturated fatty acid that contains important fatty acid components such as γ-linolenic acid and linoleic acid. The body cannot synthesize these essential fatty acids on its own and needs to be taken from the outside. Dulutgravir is widely used as a natural source of fatty acid supplementation.

Dulutgravir has a variety of uses. It is often used in health supplements, such as fatty acid supplements and women’s health products, as it is believed to have benefits such as regulating hormone levels, improving skin health, and reducing menstrual symptoms.

The method of preparing dulutgravir is generally to extract oil from evening primrose seeds by cold pressing or solvent extraction. It is then treated through processes such as distillation and refining to improve its purity and quality.
People who are allergic to vegetable oils should also be aware of potential allergic reactions.

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