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dabigatran etexilate（CAS# 211915-06-9) Featured Image
  • dabigatran etexilate（CAS# 211915-06-9) 1

dabigatran etexilate（CAS# 211915-06-9)

Chemical Property:

Molecular Formula C34H41N7O5
Molar Mass 627.73
Density 1.24±0.1 g/cm3(Predicted)
Melting Point 128-129°
Boling Point 827.9°C at 760 mmHg
Flash Point 454.5°C
Solubility DMSO (Slightly), Methanol (Slightly)
Vapor Presure 1.49E-27mmHg at 25°C
Appearance Solid
Color White to Pale Yellow
pKa 9.88±0.46(Predicted)
Storage Condition Sealed in dry,Store in freezer, under -20°C
Stability Hygroscopic
Refractive Index 1.614
In vitro study Dabigatran selectively and reversibly inhibits human thrombin (Ki: 4.5 nM) and thrombin-induced platelet aggregation (IC50: 10 nM) and has no inhibitory effect on other platelet stimulating agents. Dabigatran inhibits the generation of (PPP) thrombin in the plasma of depleted platelets with an IC50 of 0.56 μm as measured by the endogenous thrombin Index (ETP). In in vitro experiments, Dabigatran has a concentration-dependent anticoagulant effect on various species. In human PPP, the activated partial thromboplastin time (aPTT), prothrombin time (PT) were doubled at concentrations of 0.23,0.83 and 0.18 μm, respectively. And Ecarin clotting time (ECT)..
In vivo study Dabigatran dose-dependently prolonged aPPT after intravenous administration in rats (0.3,1 and 3 mg/kg) and rhesus monkeys (0.15,0.3 and 0.6 mg/kg). Dabigatran etexilate (20 mg/kg, P. O.) produced less prolongation of the k value and less attenuation of the maximum increase in pigs than enoxaparin. Dabigatran(0.01-0.1 mg/kg) dose-dependently reduced thrombosis, with ED50 (50% effective dose) being 0.033 mg/kg and complete inhibition at 0.1 mg/kg. Dabigatran etexilate (5-30 mg/kg) inhibited thrombus formation in a dose-and time-dependent manner, with maximal inhibition occurring after 30 min of pretreatment, indicating a faster acting effect.

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Introduction

Dibutyl phthalate is an organic compound. It is a colorless to light yellow liquid with a special fragrance.

 

Dabigatran etexilate is mainly used as a plasticizer. It can enhance the softness and ductility of plastics, so it is widely used in the manufacture of plastic products, such as plastic films, plastic pipes, plastic flooring and plastic shoes. It can also be used as an additive to solvents, lubricants and fragrances.

 

Dabigatran etexilate is usually prepared by esterification of phthalic anhydride with n-butanol or isobutanol. The reaction is usually carried out in the presence of an acid catalyst at the appropriate temperature and pressure.

It can be irritating to the skin and eyes and should be rinsed with plenty of water immediately after contact. Avoid reacting with oxidants, avoiding ignition sources and away from high temperatures and open flames during operation and storage. It should be well ventilated during use to avoid vapor accumulation.

 

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