Phone:+86 21 6460 6569
page_banner

product

D-Glutamine（CAS# 5959-95-5) Featured Image
  • D-Glutamine（CAS# 5959-95-5) 1

D-Glutamine（CAS# 5959-95-5)

Chemical Property:

Molecular Formula C5 H10 N2 O3
Molar Mass 146.14
Density 1.3394 (rough estimate)
Melting Point 184-185 °C
Boling Point 265.74°C (rough estimate)
Specific Rotation(α) -32 º (589nm, c=10, N HCl)
Water Solubility 42.53g/L(temperature not stated)
Solubility Soluble in water (9 mg/ml at 25 °C), DMSO (<1 mg/ml at 25 °C), and ethanol (<1 mg/m
Appearance White crystalline powder
Color White
BRN 1723796
pKa 2.27±0.10(Predicted)
Storage Condition Keep in dark place,Inert atmosphere,Room temperature
Refractive Index -33 ° (C=5, 5mol/L H
MDL MFCD00065607
Physical and Chemical Properties Melting Point: 185
In vitro study Glutamine is a key amino acid in the central nervous system (CNS), playing an important role in the glutamate/GABA-Glutamine cycle (GGC). In the GGC,Glutamine is transferred from astrocytes to neurons, where it will replenish the inhibitory and excitatory neurotransmitter pools. D-Glutamine has been used to study its role in conferring protection against acetaldehyde-induced disruption of barrier function in Caco-2 cell monolayer. Role of L-Glutamine in the protection of intestinal epithelium from acetaldehyde-induced disruption of barrier function is evaluated in Caco-2 cell monolayer. L-Glutamine reduced the acetaldehyde-induced decrease in transepithelilal electrical resistance and increase in permeability to inulin and lipopolysaccharide in a time- and dose-dependent manner; D-Glutamine, L-aspargine, L-arginine, L-lysine, or L-alanine produced no significant protection. D-Glutamine also fails to influence the acetaldehyde-induced decrease in TER and increase in inulin flux. D-Glutamine or glutaminase inhibitor by themselves did not influence TER or inulin flux in control or acetaldehyde-treated cell monolayers. Lack of effect of D-Glutamine in protection from acetaldehyde indicates that the L-Glutamine-mediated protection is stereospecific.

Product Detail

Product Tags

Hazard Symbols Xi – Irritant
Risk Codes 36/37/38 – Irritating to eyes, respiratory system and skin.
Safety Description S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27 – Take off immediately all contaminated clothing.
S24/25 – Avoid contact with skin and eyes.
WGK Germany 3
HS Code 29241900

 

Introduction

The unnatural isomer of glutamine is actually insoluble in methanol, ethanol, ether and benzene.

  • Previous:
  • Next:
    • Write your message here and send it to us

    related products