Cbz-L-Glutamic acid 1-benzyl ester（CAS# 3705-42-8)
Introduction
Z-Glu-OBzl(Z-Glu-OBzl) is an organic compound commonly used as a protecting group for amino acids. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Molecular formula: C17H17NO4
-Molecular weight: 303.32g/mol
-Appearance: White crystalline powder
-Melting Point: 84-85°C
-Solubility: Soluble in organic solvents such as dimethyl sulfoxide and dimethylformamide
- Cbz protecting group can be removed by palladium hydride catalyst under acidic conditions
Use:
- Z-Glu-OBzl is a protecting group of glutamic acid (Glu), which can be used in the synthesis of amino acid derivatives, polypeptides and proteins.
-As a protecting group for amino acids in synthetic organic compounds, it can protect the amine group of glutamic acid, prevent it from being affected by non-specific reactions, and facilitate removal when needed.
Preparation Method:
-The preparation of Z-Glu-OBzl usually includes a multi-step process and involves a series of chemical reactions. One of the common methods is to first protect the carboxyl group of glutamic acid as t-butoxycarbonyl ester (Boc) and then protect the amino group as Cbz. Finally, the desired product Z-Glu-OBzl is formed by reaction with benzyl chloroformate.
Safety Information:
- Z-Glu-OBzl should be treated as irritating compounds and avoid direct contact with skin and eyes.
-When used in the laboratory, correct safety procedures must be followed, including wearing protective glasses, gloves and laboratory coats.
-Inhalation or ingestion of the compound should be avoided and fire and explosion prevention measures should be taken during storage.
-The compound should be placed in a well-ventilated environment during processing, and waste should be properly disposed of in accordance with local regulations.
