Boc-N-beta-Trityl-L-asparagine (CAS# 132388-68-2)
Risk and Safety
| Safety Description | S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2924 29 70 |
| Hazard Class | IRRITANT |
Introduction
Boc-Phe-OtBu is hydrophobic and hardly soluble in water, but easily soluble in organic solvents such as methanol, ethanol and dichloromethane. It is relatively stable to light and heat.
Use:
Boc-Phe-OtBu are mainly used for protecting groups and reaction intermediates in organic synthesis. In the synthesis, it can be used to protect aromatic amino acids, in the synthesis of polypeptides and proteins, protecting the active groups to prevent the occurrence of side reactions. In addition, it can also be used to prepare other compounds, such as drugs, dyes and organic materials.
Preparation Method:
The preparation of Boc-Phe-OtBu is mainly accomplished by chemical reaction. One common method is to react p-benzoic acid with t-butyl hydroxyformate to produce p-tert-butoxycarbonyl benzoate. It is then reacted with triphenylamine to give the final product Boc-Phe-OtBu.
Safety Information:
The Boc-Phe-OtBu is relatively safe under normal use. However, as a chemical, it still needs to be stored and handled properly. Avoid contact with strong oxidants, prevent inhalation of dust and avoid skin contact. During use, wear appropriate personal protective equipment, such as gloves and protective glasses. In the event of accidental contact or ingestion, seek medical advice immediately and provide information to the doctor about the chemical. Local safety rules and regulations should be followed when handling and disposing of waste.
