Boc-L-Glutamic acid（CAS# 2419-94-5)
| Hazard Symbols | Xn – Harmful |
| Risk Codes | R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. S36 – Wear suitable protective clothing. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S4/25 - |
| WGK Germany | 3 |
| HS Code | 29241990 |
Introduction
Boc-L-glutamic acid is an organic compound with the chemical name tert-butoxycarbonyl-L-glutamic acid. The following is an introduction to the properties, uses, preparation methods and safety information of Boc-L-glutamic acid:
Quality:
Boc-L-glutamic acid is a white crystalline solid that is soluble in some organic solvents such as methanol, ethanol, and dimethyl sulfoxide. It is relatively stable at room temperature, but may decompose at high temperatures.
Use:
Boc-L-glutamic acid is a protective compound that is commonly used in peptide synthesis reactions in organic synthesis. It protects the carboxyl group of glutamic acid, thus preventing it from side reactions in the reaction. Once the reaction is complete, the Boc protecting group can be removed by acid or hydrogenation reactions, resulting in the formation of the peptide of interest.
Method:
Boc-L-glutamic acid can be obtained by reacting L-glutamic acid with tert-butylhydroxycarbamoyl (BOC-ON). The reaction takes place in an organic solvent, usually at low temperatures, and is catalyzed by a base.
Safety Information:
The use of Boc-L-glutamate should follow laboratory safety protocols. Its dust can be irritating to the respiratory system, eyes and skin, and personal protective equipment such as respirators, protective glasses and gloves should be worn when handling. It should be stored in a dry, cool place to avoid contact with oxidants and strong acids and bases. In case of accidental ingestion or contact with skin, seek medical attention or consult a professional immediately.
