BOC-GLY-GLY-GLY-OH（CAS# 28320-73-2)

Introduction

Tert-Butoxycarbonylglycyl glycylglycine (Boc-Gly-Gly-Gly-OH) is an organic compound with the following properties:

Nature:

-Appearance: usually white crystal or crystalline powder

-Molecular formula: C17H30N4O7

-Molecular weight: 402.44g/mol

-Melting point: about 130-132 ° C

-Solubility: Soluble in organic solvents such as dimethylformamide (DMF), dichloromethane, chloroform, etc., insoluble in water.

Use:

Boc-Gly-Gly-Gly-OH are commonly used in organic synthesis, mainly as protecting groups or groups. It can be used as a protective group of amino acids to prevent non-specific reactions, and is commonly used in solid phase synthesis, peptide synthesis and drug synthesis.

Method:

A common method for preparing Boc-Gly-Gly-Gly-OH is to introduce a tert-butoxycarbonyl protecting group on the carboxyl group of glycine. Specific steps include:

1. Glycine is reacted with a mixture of sodium nitrite and sulfuric acid to obtain tert-butoxycarbonyl glycinate.

2. The Ester protecting group is removed by a hydrolysis reaction to obtain Boc-glycine.

3. Repeat the above steps twice to introduce the carboxyl group of glycine into two tert-butoxycarbonyl protecting groups respectively to obtain Boc-Gly-Gly-Gly-OH.

Safety Information:

The use of Boc-Gly-Gly-Gly-OH should pay attention to the following safety matters:

-Avoid contact with skin and eyes, as it may irritate the skin and eyes.

-Wear appropriate protective gloves, goggles and protective clothing during operation.

-Operate in a well-ventilated place to avoid inhaling its dust or vapor.

-should be stored away from fire, heat and oxidant, keep the container sealed, stored in a cool, dry place.