alpha-Arbutin（CAS# 84380-01-8)
Risk and Safety
| WGK Germany | 3 |
Information
| Overview | arbutin is a hydroquinone glycoside compound, chemical name for 4-hydroxyphenyl-d-glucopyranoside (y), exists in bear fruit, bilberry and other plants, is a new non-irritating, non-allergic, natural whitening active substances with strong compatibility. Arbutin has two structural and functional functional groups in its molecular structure: one is a glucose residue; The other is a phenolic hydroxyl group. The physical state of α-arbutin appears as a white to light gray powder, which is more soluble in water and ethanol. |
| efficacy | α-arbutin has a better therapeutic effect on scars caused by UV Burns, has a better anti-inflammatory, repair and whitening effect. Can inhibit the production and deposition of melanin, remove spots and freckles. |
| mechanism of action | The whitening mechanism of α-arbutin directly inhibits tyrosinase activity, thereby reducing the production of melanin, rather than reducing melanin production by inhibiting cell growth or tyrosinase gene expression. As α-Arbutin is a more efficient and safer whitening active substance, many cosmetic companies at home and abroad have adopted α-arbutin instead of β-arbutin as a whitening additive. |
| Application | alpha-Arbutin is a chemical that is similar to arbutin, can inhibit the production and deposition of melanin, remove spots and freckles. The results show that arbutin can inhibit the activity of tyrosinase at relatively low concentration, and its inhibitory effect on tyrosinase is better than that of arbutin. alpha-arbutin can be used as a whitening agent in cosmetics. |
| purification and identification | the sample obtained by the reaction was first extracted with ethyl acetate, then extracted with n-butanol, the samples were collected by evaporation on a rotary evaporator and centrifuged. The supernatant was analyzed by HPLC and compared with the HPLC chromatogram of α-arbutin, whether the sample and α-arbutin have the same retention time is compared, and whether the sample contains α-Arbutin is preliminarily inferred.
The product after extraction and purification was identified by positive ion mode of LC-ESI-MS/MS. By comparing the relative molecular mass of α-bear fruit with the relative molecular mass of α-arbutin standard, it can be determined whether the product is α-arbutin. |
| Usage | α-arbutin can inhibit tyrosinase activity at relatively low concentration, its inhibitory effect on tyrosinase is better than that of arbutin |
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