7-Bromo-1-chloroisoquinoline(CAS#215453-51-3)
| Hazard Symbols | T – Toxic |
| Risk Codes | R36/37/38 – Irritating to eyes, respiratory system and skin. R41 – Risk of serious damage to eyes R37/38 – Irritating to respiratory system and skin. R25 – Toxic if swallowed |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37 – Wear suitable gloves. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S39 – Wear eye / face protection. |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
Introduction
It is an organic compound with the chemical formula C9H5BrClN. The following describes the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless to yellowish solid.
-Melting point: about 81-83°C.
-Boiling point: About 324-326 ℃.
-Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and dichloromethane.
Use:
-is often used in organic synthesis as an intermediate or starting material.
-The compound can be used to prepare organic compounds such as pesticides, medicines and dyes.
Method:
There are many preparation methods, one of which is briefly described below:
-First, 1-chloroisoquinoline is reacted with bromine under alkaline conditions. Alkali metal carbonates such as potassium carbonate or sodium carbonate are often used as bases. The reaction needs to be carried out in a suitable solvent, such as an alcohol or ketone solvent.
-During the reaction process, 1-bromoisoquinoline is first generated, and then a substitution reaction occurs to replace the bromine atom with the chlorine atom, thereby generating the bromine atom.
-Finally, the reaction product is subjected to appropriate operations, such as Crystal separation or solvent distillation, to obtain pure quartz.
Safety Information:
-may be potentially harmful to the human body, so pay attention to safety measures during use and storage.
-Contact with skin may cause irritation or allergic reactions. Wear appropriate protective gloves and clothing for use.
-Because it is flammable, it should be kept away from open flames or high temperature spots.
-This compound may have an adverse impact on the environment, and waste should be properly handled and disposed.
