6-bromopyridine-2-carboxylic acid ethyl ester（CAS# 21190-88-5)
| Hazard Symbols | Xi – Irritant |
| Risk Codes | 36 – Irritating to the eyes |
| Safety Description | 26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
Introduction
acid ethyl ester is an organic compound with the chemical formula C8H8BrNO2. It is a colorless liquid with a special smell. The compound is soluble in organic solvents such as ethanol, dimethylformamide and benzene, and insoluble in water.
acid ethyl ester has a wide range of applications in organic synthesis. It can be used as a pharmaceutical intermediate for the synthesis of a wide range of drugs and bioactive molecules. In addition, it can also be used in the Gormperman reaction and palladium-catalyzed cross-coupling reactions in organic synthesis.
There are two common methods for acid ethyl ester:
1. It is obtained by the reaction of 6-bromopyridine and chloroacetate, and then hydrolyzed with alkali after the reaction.
2. By 6-bromopyridine and chloroacetic acid ester reaction, acid chloride, and then react with alcohol to obtain the product.
Safety precautions are required when using and storing acid ethyl ester. It is a flammable liquid and should be stored in a cool, well-ventilated place, away from fire and high temperatures. Appropriate protective equipment, such as lab gloves and goggles, should be worn during operation. If ingestion or contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
