3-Chloro-5-trifluoromethylpyridine-2-carboxylic acid ethyl ester（CAS#128073-16-5）
| Hazard Symbols | Xi – Irritant |
Introduction
Ethyl 3-chloro-5-trifluoromethylpyridin-2-carboxylate, also known as Fmoc-Cl. The following is an introduction to its properties, uses, manufacturing methods and safety information:
Quality:
Appearance: Colorless liquid.
Solubility: Soluble in organic solvents.
Use:
FMOC-CL is an important protecting group in organic synthesis. It can react with oxyamine to generate Fmoc protective derivatives of amino acids or peptides for solid-phase synthesis.
It can also be used in the protecting radical chemistry of other chemical synthesis reactions.
Method:
The synthesis of FMOC-CL typically involves the following steps:
The hydrochloride of 3-chloro-5-trifluoromethylpyridine-2-carboxylic acid was prepared first.
Hydrochloride is reacted with a base (e.g., triethylamine) to form Fmoc-Cl.
Safety Information:
FMOC-CL may be irritating to the skin, eyes, and mucous membranes, so wear protective gloves and goggles when using it.
Avoid inhalation and contact during operation, and keep it well ventilated.
In case of inhalation or skin contact, rinse immediately with clean water and seek medical attention immediately.
When storing, it should be sealed and kept away from heat and fire.
Always be aware of safety and follow relevant safety operating procedures when using or handling any chemical substances.
