5-Bromo-3-nitro-2-pyridinol（CAS# 15862-34-7)
Risk and Safety
| Risk Codes | R22 – Harmful if swallowed R37/38 – Irritating to respiratory system and skin. R41 – Risk of serious damage to eyes R36/37/38 – Irritating to eyes, respiratory system and skin. R20 – Harmful by inhalation |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S36 – Wear suitable protective clothing. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| HS Code | 29337900 |
| Hazard Note | Harmful |
| Hazard Class | IRRITANT |
Reference Information
| Use | 5-bromo-2-hydroxy-3-nitropyridine is an organic intermediate that can be used to prepare compounds 3-amino-1-(2-oxo-2-(3 ‘-(trifluoromethyl)-[1,1'-biphenyl]-4-yl) ethyl)-5-(pyrrole alkyl-1-yl-sulfonyl) pyridin-2 (1H)-one, this compound is a DOCK1 inhibitory compound. |
| synthesis method | nitric acid (60-61%,3.5mL) was added to the solution (10mL) of 5-bromopyridine -2(1H)-one (1.75g,10.1mmol) in sulfuric acid at 0 ℃. The mixture is allowed to be heated to room temperature and stirred for 3 hours. The reaction mixture is poured into ice water and the resulting precipitate is collected by filtration. The resulting product was washed with water and dried in vacuum, giving 5-bromo-2-hydroxy-3-nitropyridine (960mg,43% yield) as a white solid. 1H NMR(500MHz,CDCl3)δ:8.57(s,1H),8.26(s,1H). |
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