5-bromo-2-pyridinecarboxylic acid ethyl ester （CAS# 77199-09-8)

Introduction

Ethyl 5-bromo-2-pyrimidincarboxylate is an organic compound. The following is some information about the properties, uses, preparation methods and safety of the compound:

Quality:

- Appearance: Ethyl 5-bromo-2-pyrimidincarboxylate is a colorless to pale yellow liquid.

- Solubility: It can be dissolved in organic solvents such as ethanol and methylene chloride, but it is insoluble in water.

Use:

- Ethyl 5-bromo-2-pyrimidincarboxylic acid is often used as an important intermediate in organic synthesis.

- It can also be used as an analytical reagent in research areas.

Method:

- The synthesis of ethyl 5-bromo-2-pyrimidincarboxylic acid can be obtained by esterification of bromobenzoic acid on a pyrimidine ring.

- In this process, p-bromobenzoic acid and isopropyl carbonate are first reacted to produce isopropyl p-bromobenzoate, and then by adding excess pyrimidine, heating to an appropriate temperature and reacting for a period of time, the final 5-bromo-2-pyrimidincarboxylate ethyl ester is obtained.

- Pay attention to the reaction temperature, reaction time, and mass ratio of reactants during preparation to obtain a product with high yield and purity.

Safety Information:

- Ethyl 5-bromo-2-pyrimidincarboxylate is an organic compound and is flammable.

- Follow routine laboratory safety practices and wear appropriate protective equipment such as gloves and goggles when using and handling.

- Avoid contact with skin, eyes, and inhalation.

- In case of accidental contact, rinse the affected area with plenty of water and seek medical attention.