5-Bromo-2-hydroxynicotinic acid(CAS#104612-36-4)

5-Bromo-2-hydroxynicotinic acid(CAS#104612-36-4)

Physical
Appearance: White powder
Density: 2.015g/cm³
Melting Point: 287°C
Boiling Point: 354.7ºC at 760mmHg
Flash Point: 287°C
Vapor pressure: 5.49e-06mmHg at 25°C
LogP：0.83560
PSA：70.16000
Chemical properties
It has the typical properties of carboxylic acid and phenolic hydroxyl group, and can undergo esterification reaction, acid-base neutralization reaction, etc. The bromine atom on its pyridine ring can undergo substitution reactions under certain conditions, such as reacting with nucleophiles and being replaced by other groups. The hydroxyl group in the molecule can form complexes with metal ions, etc. In addition, the acidity coefficient pKa of the substance is 2.09±0.201.
Fields of application
It is mainly used as a pharmaceutical intermediate, which can be used to synthesize a variety of biologically active compounds and drugs. For example, in the synthesis route of some new antimicrobial drugs, anti-inflammatory drugs or drugs for the treatment of cardiovascular diseases, they can be used as key starting materials or intermediates to introduce specific functional groups or construct specific structures of drug molecules through a series of chemical reactions to give drugs corresponding pharmacological activity.
Storage conditions
It should be stored in a cold and dry place, and it is usually recommended to store it at room temperature in an inert gas atmosphere to avoid contact with air, moisture, etc., to prevent it from deteriorating or degrading reactions