5-amino-2-fluorobenzoic acid（CAS# 56741-33-4)
| Risk Codes | R36/37/38 – Irritating to eyes, respiratory system and skin. R22 – Harmful if swallowed |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing. S37 – Wear suitable gloves. |
| HS Code | 29163990 |
| Hazard Note | Irritant |
Introduction
5-amino-2-fluorobenzoic acid is an organic compound with the chemical formula C7H6FNO2. It is a white crystalline solid, stable at room temperature. The following is a description of its nature, use, preparation and safety information:
Nature:
1. Appearance: 5-amino-2-fluorobenzoic acid is a white crystalline solid.
2. Solubility: It has low solubility in water and can be slightly soluble in organic solvents such as ethanol and ketone.
3. Thermal stability: It has good thermal stability and is not easy to decompose during heating.
Use:
5-amino-2-fluorobenzoic acid is an important intermediate in organic synthesis and is commonly used in the pharmaceutical and dye industries.
1. Pharmaceutical applications: It can be used to synthesize some drugs, such as clozapine.
2. Dye application: It can be used as a dye precursor for the synthesis of some colored dyes.
Preparation Method:
The preparation methods of 5-amino-2-fluorobenzoic acid mainly include the following:
1. Fluorination reaction: 2-fluorobenzoic acid and ammonia are reacted together with a catalyst to obtain 5-amino-2-fluorobenzoic acid.
2. diazo reaction: first prepare the diazo compound of 2-fluorobenzoic acid, and then react with ammonia to generate 5-amino-2-fluorobenzoic acid.
Safety Information:
The safety information on 5-amino-2-fluorobenzoic acid needs further research and experimental verification. In use should pay attention to the following points:
1. Avoid contact: avoid contact with skin, eyes and respiratory tract. Rinse with clean water immediately after contact.
2. Storage Note: Store in a dry, cool place, away from fire and flammable materials.
3. operation note: in the use of the process should wear protective gloves, glasses and masks, to ensure good ventilation.
