4-(Trifluoromethoxy)benzyl chloride（CAS# 65796-00-1)
| Hazard Symbols | C – Corrosive |
| Risk Codes | 34 – Causes burns |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 1760 |
| Hazard Note | Corrosive |
| Hazard Class | 8 |
| Packing Group | III |
Introduction
Trifluoromethoxybenzyl chloride, chemical formula C8H5ClF3O, is an organic compound with the following properties and uses:
Nature:
-Appearance: colorless liquid
-Melting point:-25°C
-Boiling Point: 87-88°C
-Density: 1.42g/cm³
-Solubility: Soluble in organic solvents such as ether and dimethylformamide
Use:
-Trifluoromethoxy benzyl chloride is an important organic synthesis intermediate, which is widely used in the synthesis of drugs and pesticides. It can be used to synthesize benzothiazole compounds, benzotriazole compounds, 4-piperidinol compounds, etc.
-Trifluoromethoxybenzyl chloride is also used as a chemical reagent and catalyst.
Preparation Method:
The preparation method of trifluoromethoxy benzyl chloride is generally prepared by reacting trifluoromethanol with benzyl chloride. The specific steps include reacting trifluoromethanol and benzyl chloride in the presence of barium chloride at low temperature for a period of time, and then distilling to obtain the product.
Safety Information:
-Trifluoromethoxybenzyl chloride is an organic chlorine compound, and attention should be paid to its irritation to the skin, eyes and respiratory system. Use appropriate protective equipment, including goggles, gloves and protective clothing.
-Avoid inhaling its vapors or touching its skin. In the case of accidental contact, rinse immediately with plenty of water and seek prompt medical attention.
-Store away from fire and oxidant, avoid high temperature and direct sunlight.
