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4-(Trifluoromethoxy)aniline(CAS# 461-82-5)

Chemical Property:

Molecular Formula C7H6F3NO
Molar Mass 177.12
Density 1.32g/mLat 20°C(lit.)
Boling Point 73-75°C10mm Hg(lit.)
Flash Point 177°F
Vapor Presure 2.97mmHg at 25°C
Appearance Liquid
Specific Gravity 1.310
Color Clear colorless to yellow
BRN 2090209
pKa 3.75±0.10(Predicted)
Storage Condition Keep in dark place,Inert atmosphere,Room temperature
Refractive Index n20/D 1.463(lit.)
Physical and Chemical Properties Density: 1.31
Boiling Point: 73 ° C. (10 mmHg)
refractive index: 464
flash point: 80 ° C.
Use For the synthesis of fluorine-containing pharmaceutical and pesticide intermediates

Product Detail

Product Tags

Risk Codes R24/25 -
R33 – Danger of cumulative effects
R38 – Irritating to the skin
R41 – Risk of serious damage to eyes
R36/37/38 – Irritating to eyes, respiratory system and skin.
R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed.
Safety Description S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36 – Wear suitable protective clothing.
UN IDs UN 2941 6.1/PG 3
WGK Germany 2
HS Code 29222900
Hazard Note Toxic
Hazard Class IRRITANT, TOXIC
Packing Group III

 

Introduction

4-Trifluoromethoxyaniline is an organic compound. The following is a brief introduction to its properties, uses, manufacturing methods and safety information:

 

Quality:

- Appearance: Colorless liquid

- Odor: Characteristic ammonia odor

- Solubility: Soluble in organic solvents such as alcohols, ethers and ketones

 

Use:

- 4-Trifluoromethoxyaniline can be used as an intermediate in organic synthesis and is often used as a fluorinating reagent in organic synthesis reactions, such as in the synthesis of catalysts in Suzuki reactions.

 

Method:

- The preparation method of 4-trifluoromethoxyaniline usually adopts an amination reaction. The product can be obtained by the reaction of aniline with trifluoromethanol.

 

Safety Information:

- 4-Trifluoromethoxyaniline: Care should be taken to avoid contact with skin and eyes, and avoid inhalation or ingestion.

- When using and storing, contact with substances such as oxidants, strong acids, strong bases, and hydrogen oxide should be avoided to prevent dangerous reactions.

- Follow chemical storage and handling regulations and keep away from fire and heat.


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